Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor

Allosteric communication within proteins is a hallmark of biochemical signaling, but the dynamic transmission pathways remain poorly characterized. We combined NMR spectroscopy and surface plasmon resonance to reveal these pathways and quantify their energetics in the glucocorticoid receptor, a tran...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Köhler, C., Carlström, G., Gunnarsson, A., Weininger, U., Tångefjord, S., Ullah, V., Lepistö, M., Karlsson, U., Papavoine, T., Edman, K., Akke, M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439413/
https://ncbi.nlm.nih.gov/pubmed/32832645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb5277
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