Efficient generation of GGTA1-deficient pigs by electroporation of the CRISPR/Cas9 system into in vitro-fertilized zygotes

BACKGROUND: Xenoantigens are a major source of concern with regard to the success of interspecific xenografts. GGTA1 encodes α1,3-galactosyltransferase, which is essential for the biosynthesis of galactosyl-alpha 1,3-galactose, the major xenoantigen causing hyperacute rejection. GGTA1-modified pigs,...

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Bibliografiska uppgifter
I publikationen:BMC Biotechnol
Huvudupphovsmän: Tanihara, Fuminori, Hirata, Maki, Nguyen, Nhien Thi, Sawamoto, Osamu, Kikuchi, Takeshi, Doi, Masako, Otoi, Takeshige
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7436961/
https://ncbi.nlm.nih.gov/pubmed/32811500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-020-00638-7
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