Galantamine-Curcumin Hybrids as Dual-Site Binding Acetylcholinesterase Inhibitors

Galantamine (GAL) and curcumin (CU) are alkaloids used to improve symptomatically neurodegenerative conditions like Alzheimer’s disease (AD). GAL acts mainly as an inhibitor of the enzyme acetylcholinesterase (AChE). CU binds to amyloid-beta (Aβ) oligomers and inhibits the formation of Aβ plaques. H...

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Gepubliceerd in:Molecules
Hoofdauteurs: Stavrakov, Georgi, Philipova, Irena, Lukarski, Atanas, Atanasova, Mariyana, Zheleva, Dimitrina, Zhivkova, Zvetanka D., Ivanov, Stefan, Atanasova, Teodora, Konstantinov, Spiro, Doytchinova, Irini
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7435983/
https://ncbi.nlm.nih.gov/pubmed/32717861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25153341
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