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Discovery of a Novel Acetylcholinesterase Inhibitor by Fragment-Based Design and Virtual Screening

Despite extensive and intensive research efforts in recent decades, there is still no effective treatment for neurodegenerative diseases. On this background, the use of drugs inhibiting the enzyme acetylcholinesterase (AChE) remains an eternal evergreen in the symptomatic treatment of mild to modera...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Stavrakov, Georgi, Philipova, Irena, Lukarski, Atanas, Atanasova, Mariyana, Georgiev, Borislav, Atanasova, Teodora, Konstantinov, Spiro, Doytchinova, Irini
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038331/
https://ncbi.nlm.nih.gov/pubmed/33916760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26072058
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