Galantamine-Curcumin Hybrids as Dual-Site Binding Acetylcholinesterase Inhibitors

Galantamine (GAL) and curcumin (CU) are alkaloids used to improve symptomatically neurodegenerative conditions like Alzheimer’s disease (AD). GAL acts mainly as an inhibitor of the enzyme acetylcholinesterase (AChE). CU binds to amyloid-beta (Aβ) oligomers and inhibits the formation of Aβ plaques. H...

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Bibliographic Details
Published in:Molecules
Main Authors: Stavrakov, Georgi, Philipova, Irena, Lukarski, Atanas, Atanasova, Mariyana, Zheleva, Dimitrina, Zhivkova, Zvetanka D., Ivanov, Stefan, Atanasova, Teodora, Konstantinov, Spiro, Doytchinova, Irini
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7435983/
https://ncbi.nlm.nih.gov/pubmed/32717861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25153341
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