Human αB-crystallin discriminates between aggregation-prone and function-preserving variants of a client protein

BACKGROUND: The eye lens crystallins are highly soluble proteins that are required to last the lifespan of an organism due to low protein turnover in the lens. Crystallin aggregation leads to formation of light-scattering aggregates known as cataract. The G18V mutation of human γS-crystallin, which...

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Bibliographic Details
Published in:Biochim Biophys Acta Gen Subj
Main Authors: Sprague-Piercy, Marc, Wong, Eric, Roskamp, Kyle W., Fakhoury, Joseph, Freites, J. Alfredo, Tobias, Douglas J., Martin, Rachel W.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434982/
https://ncbi.nlm.nih.gov/pubmed/31812542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2019.129502
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