Multiple Aggregation Pathways in Human γS-Crystallin and Its Aggregation-Prone G18V Variant

PURPOSE: Cataract results from the formation of light-scattering precipitates due to point mutations or accumulated damage in the structural crystallins of the eye lens. Although excised cataracts are predominantly amorphous, in vitro studies show that crystallins are capable of adopting a variety o...

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Bibliografske podrobnosti
izdano v:Invest Ophthalmol Vis Sci
Main Authors: Roskamp, Kyle W., Montelongo, David M., Anorma, Chelsea D., Bandak, Diana N., Chua, Janine A., Malecha, Kurtis T., Martin, Rachel W.
Format: Artigo
Jezik:Inglês
Izdano: The Association for Research in Vision and Ophthalmology 2017
Teme:
Lens
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407245/
https://ncbi.nlm.nih.gov/pubmed/28444328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20621
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