Multiple Aggregation Pathways in Human γS-Crystallin and Its Aggregation-Prone G18V Variant

PURPOSE: Cataract results from the formation of light-scattering precipitates due to point mutations or accumulated damage in the structural crystallins of the eye lens. Although excised cataracts are predominantly amorphous, in vitro studies show that crystallins are capable of adopting a variety o...

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Detalles Bibliográficos
Publicado en:Invest Ophthalmol Vis Sci
Main Authors: Roskamp, Kyle W., Montelongo, David M., Anorma, Chelsea D., Bandak, Diana N., Chua, Janine A., Malecha, Kurtis T., Martin, Rachel W.
Formato: Artigo
Idioma:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2017
Assuntos:
Lens
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407245/
https://ncbi.nlm.nih.gov/pubmed/28444328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20621
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