Human αB-crystallin discriminates between aggregation-prone and function-preserving variants of a client protein

BACKGROUND: The eye lens crystallins are highly soluble proteins that are required to last the lifespan of an organism due to low protein turnover in the lens. Crystallin aggregation leads to formation of light-scattering aggregates known as cataract. The G18V mutation of human γS-crystallin, which...

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I publikationen:Biochim Biophys Acta Gen Subj
Huvudupphovsmän: Sprague-Piercy, Marc, Wong, Eric, Roskamp, Kyle W., Fakhoury, Joseph, Freites, J. Alfredo, Tobias, Douglas J., Martin, Rachel W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434982/
https://ncbi.nlm.nih.gov/pubmed/31812542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2019.129502
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