Human αB-crystallin discriminates between aggregation-prone and function-preserving variants of a client protein

BACKGROUND: The eye lens crystallins are highly soluble proteins that are required to last the lifespan of an organism due to low protein turnover in the lens. Crystallin aggregation leads to formation of light-scattering aggregates known as cataract. The G18V mutation of human γS-crystallin, which...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Biochim Biophys Acta Gen Subj
Hlavní autoři: Sprague-Piercy, Marc, Wong, Eric, Roskamp, Kyle W., Fakhoury, Joseph, Freites, J. Alfredo, Tobias, Douglas J., Martin, Rachel W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434982/
https://ncbi.nlm.nih.gov/pubmed/31812542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2019.129502
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky