Separating Instability from Aggregation Propensity in γS-Crystallin Variants

Molecular dynamics (MD) simulations, circular dichroism (CD), and dynamic light scattering (DLS) measurements were used to investigate the aggregation propensity of the eye-lens protein γS-crystallin. The wild-type protein was investigated along with the cataract-related G18V variant and the symmetr...

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Detalhes bibliográficos
Main Authors: Brubaker, William D., Freites, J. Alfredo, Golchert, Kory J., Shapiro, Rebecca A., Morikis, Vasilios, Tobias, Douglas J., Martin, Rachel W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021659/
https://ncbi.nlm.nih.gov/pubmed/21244846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.12.3691
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