Increased hydrophobic surface exposure in the cataract-related G18V variant of human γS-crystallin

BACKGROUND: The objective of this study was to determine whether the cataract-related G18V variant of human γS-crystallin has increased exposure of hydrophobic residues that could explain its aggregation propensity and/or recognition by αB-crystallin. METHODS: We used an ANS fluorescence assay and N...

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Khago, Domarin, Wong, Eric K., Kingsley, Carolyn N., Freites, J. Alfredo, Tobias, Douglas J., Martin, Rachel W.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942885/
https://ncbi.nlm.nih.gov/pubmed/26459004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2015.09.022
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