Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

Members of the family of pyrin and HIN domain containing (PYHIN) proteins play an emerging role in innate immunity. While absent in melanoma 2 (AIM2) acts a cytosolic sensor of non-self DNA and plays a key role in inflammasome assembly, the γ-interferon-inducible protein 16 (IFI16) restricts retrovi...

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Detaylı Bibliyografya
Yayımlandı:PLoS Pathog
Asıl Yazarlar: Bosso, Matteo, Prelli Bozzo, Caterina, Hotter, Dominik, Volcic, Meta, Stürzel, Christina M., Rammelt, Annika, Ni, Yi, Urban, Stephan, Becker, Miriam, Schelhaas, Mario, Wittmann, Sabine, Christensen, Maria H., Schmidt, Florian I., Gramberg, Thomas, Sparrer, Konstantin M. J., Sauter, Daniel, Kirchhoff, Frank
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433898/
https://ncbi.nlm.nih.gov/pubmed/32760121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008752
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