Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

Members of the family of pyrin and HIN domain containing (PYHIN) proteins play an emerging role in innate immunity. While absent in melanoma 2 (AIM2) acts a cytosolic sensor of non-self DNA and plays a key role in inflammasome assembly, the γ-interferon-inducible protein 16 (IFI16) restricts retrovi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Bosso, Matteo, Prelli Bozzo, Caterina, Hotter, Dominik, Volcic, Meta, Stürzel, Christina M., Rammelt, Annika, Ni, Yi, Urban, Stephan, Becker, Miriam, Schelhaas, Mario, Wittmann, Sabine, Christensen, Maria H., Schmidt, Florian I., Gramberg, Thomas, Sparrer, Konstantin M. J., Sauter, Daniel, Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433898/
https://ncbi.nlm.nih.gov/pubmed/32760121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008752
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados