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HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3

It has been reported that HIV-1 Vpu mediates the degradation of interferon regulatory factor 3 (IRF-3) to avoid innate immune sensing. Here, we show that Vpu does not deplete IRF-3 from transfected cell lines or HIV-1-infected primary cells. Furthermore, the Vpu-dependent suppression of beta interfe...

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Detalhes bibliográficos
Main Authors: Hotter, Dominik, Kirchhoff, Frank, Sauter, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676088/
https://ncbi.nlm.nih.gov/pubmed/23552418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00526-13
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