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Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1
To avoid innate sensing and immune control, HIV-1 has to prevent the accumulation of viral cDNA species. Here, we show that the late HIV-1 accessory protein Vpu hijacks DNA repair mechanisms to promote degradation of nuclear viral cDNA in cells that are already productively infected. Vpu achieves th...
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| Опубликовано в: : | Nat Microbiol |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616938/ https://ncbi.nlm.nih.gov/pubmed/32690953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-0753-6 |
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