Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1

To avoid innate sensing and immune control, HIV-1 has to prevent the accumulation of viral cDNA species. Here, we show that the late HIV-1 accessory protein Vpu hijacks DNA repair mechanisms to promote degradation of nuclear viral cDNA in cells that are already productively infected. Vpu achieves th...

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Publicat a:Nat Microbiol
Autors principals: Volcic, Meta, Sparrer, Konstantin M. J., Koepke, Lennart, Hotter, Dominik, Sauter, Daniel, Stürzel, Christina M., Scherer, Myriam, Stamminger, Thomas, Hofmann, Thomas G., Arhel, Nathalie, Wiesmüller, Lisa, Kirchhoff, Frank
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616938/
https://ncbi.nlm.nih.gov/pubmed/32690953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-0753-6
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