Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic antibody mimetics, termed monobodies, to interfere with STAT3 signaling. These monobodies are h...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: La Sala, Grégory, Michiels, Camille, Kükenshöner, Tim, Brandstoetter, Tania, Maurer, Barbara, Koide, Akiko, Lau, Kelvin, Pojer, Florence, Koide, Shohei, Sexl, Veronika, Dumoutier, Laure, Hantschel, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431413/
https://ncbi.nlm.nih.gov/pubmed/32807795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17920-z
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