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Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains
The dysregulated tyrosine kinase BCR-ABL causes chronic myelogenous leukemia in humans and forms a large multiprotein complex that includes the Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2). The expression of SHP2 is necessary for BCR-ABL-dependent oncogenic transformation, but the pre...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773763/ https://ncbi.nlm.nih.gov/pubmed/23980151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303640110 |
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