Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains

The dysregulated tyrosine kinase BCR-ABL causes chronic myelogenous leukemia in humans and forms a large multiprotein complex that includes the Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2). The expression of SHP2 is necessary for BCR-ABL-dependent oncogenic transformation, but the pre...

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Autores principales: Sha, Fern, Gencer, Emel Basak, Georgeon, Sandrine, Koide, Akiko, Yasui, Norihisa, Koide, Shohei, Hantschel, Oliver
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773763/
https://ncbi.nlm.nih.gov/pubmed/23980151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303640110
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