Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

The binding of Src-homology 2 (SH2) domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the eight Src family kinases (SFKs). The high sequence conservation of the 120 human SH2 domains poses a significant challenge to selectively perturb the interact...

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Foilsithe in:J Mol Biol
Main Authors: Kükenshöner, Tim, Schmit, Nadine Eliane, Bouda, Emilie, Sha, Fern, Pojer, Florence, Koide, Akiko, Seeliger, Markus, Koide, Shohei, Hantschel, Oliver
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417323/
https://ncbi.nlm.nih.gov/pubmed/28347651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.03.023
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