Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1

UHRF1 is an important epigenetic regulator associated with apoptosis and tumour development. It is a multidomain protein that integrates readout of different histone modification states and DNA methylation with enzymatic histone ubiquitylation activity. Emerging evidence indicates that the chromatin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Tauber, Maria, Kreuz, Sarah, Lemak, Alexander, Mandal, Papita, Yerkesh, Zhadyra, Veluchamy, Alaguraj, Al-Gashgari, Bothayna, Aljahani, Abrar, Cortés-Medina, Lorena V, Azhibek, Dulat, Fan, Lixin, Ong, Michelle S, Duan, Shili, Houliston, Scott, Arrowsmith, Cheryl H, Fischle, Wolfgang
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Gene regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430637/
https://ncbi.nlm.nih.gov/pubmed/32609811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa520
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