An allosteric interaction links USP7 to deubiquitination and chromatin targeting of UHRF1

The protein stability and chromatin functions of UHRF1 (Ubiquitin-like, containing PHD and RING Finger domains, 1) are regulated in a cell cycle-dependent manner. We report a structural characterization of the complex between UHRF1 and the deubiquitinase USP7. The first two UBL domains of USP7 bind...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Zhang, Zhi-Min, Rothbart, Scott B., Allison, David F., Cai, Qian, Harrison, Joseph S., Li, Lin, Wang, Yinsheng, Strahl, Brian D., Wang, Gang Greg, Song, Jikui
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558366/
https://ncbi.nlm.nih.gov/pubmed/26299963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.046
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