載入...

Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation

Checkpoint kinase 1 (CHK1), a Ser/Thr protein kinase, is modified by the K63-linked ubiquitin chain in response to genotoxic stress, which promotes its nuclear localization, chromatin association, and activation. Interestingly, this bulky modification is linked to a critical residue, K132, at the ki...

全面介紹

Na minha lista:
書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Cheng, Yu-Che, Shieh, Sheau-Yann
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003459/
https://ncbi.nlm.nih.gov/pubmed/29735693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719856115
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!