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Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation
Checkpoint kinase 1 (CHK1), a Ser/Thr protein kinase, is modified by the K63-linked ubiquitin chain in response to genotoxic stress, which promotes its nuclear localization, chromatin association, and activation. Interestingly, this bulky modification is linked to a critical residue, K132, at the ki...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6003459/ https://ncbi.nlm.nih.gov/pubmed/29735693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719856115 |
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