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USP7 controls Chk1 protein stability by direct deubiquitination
Chk1, an essential checkpoint kinase in the DNA damage response pathway (DDR), is tightly regulated by both ATR-dependent phosphorylation and proteasome-mediated degradation. Here we identify ubiquitin hydrolase USP7 as a novel regulator of Chk1 protein stability. USP7 was shown before to regulate o...
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| 出版年: | Cell Cycle |
|---|---|
| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4614819/ https://ncbi.nlm.nih.gov/pubmed/25483066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.973324 |
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