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Dub3 controls DNA damage signalling by direct deubiquitination of H2AX
A crucial event in the DNA damage response is the phosphorylation and subsequent ubiquitination of H2AX, required for the recruitment of proteins involved in DNA repair. Here we identify a novel regulator of this process, the ubiquitin hydrolase Dub3. Overexpression of wild type, but not catalytic i...
Gespeichert in:
| Veröffentlicht in: | Mol Oncol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5528525/ https://ncbi.nlm.nih.gov/pubmed/24704006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.03.003 |
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