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Monoubiquitination of H2AX Protein Regulates DNA Damage Response Signaling
Double strand breaks (DSBs) are the most deleterious of the DNA lesions that initiate genomic instability and promote tumorigenesis. Cells have evolved a complex protein network to detect, signal, and repair DSBs. In mammalian cells, a key component in this network is H2AX, which becomes rapidly pho...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3151101/ https://ncbi.nlm.nih.gov/pubmed/21676867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.256297 |
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