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Phosphorylation at Threonine 288 by Cell Cycle Checkpoint Kinase 2 (CHK2) Controls Human Monopolar Spindle 1 (Mps1) Kinetochore Localization

Human Mps1 (hMps1) is a mitotic checkpoint kinase responsible for sensing the unattached and tensionless kinetochore. Despite its importance in safeguarding proper chromosome segregation, how hMps1 is recruited to the kinetochore remains incompletely understood. Here, we demonstrate that phosphoryla...

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Main Authors: Yeh, Chun-Wei, Yu, Zheng-Cheng, Chen, Peng-Hsu, Cheng, Yu-Che, Shieh, Sheau-Yann
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140889/
https://ncbi.nlm.nih.gov/pubmed/24764296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.552273
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