Enhanced Generation of Induced Cardiomyocytes Using a Small‐Molecule Cocktail to Overcome Barriers to Cardiac Cellular Reprogramming

BACKGROUND: Given known inefficiencies in reprogramming of fibroblasts into mature induced cardiomyocytes (iCMs), we sought to identify small molecules that would overcome these barriers to cardiac cell transdifferentiation. METHODS AND RESULTS: We screened alternative combinations of compounds know...

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Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Singh, Vivek P., Pinnamaneni, Jaya Pratap, Pugazenthi, Aarthi, Sanagasetti, Deepthi, Mathison, Megumi, Wang, Kai, Yang, Jianchang, Rosengart, Todd K.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429035/
https://ncbi.nlm.nih.gov/pubmed/32500803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015686
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