p63 Silencing Induces Reprogramming of Cardiac Fibroblasts into Cardiomyocyte –Like Cells

OBJECTIVE: Reprogramming of fibroblasts into induced cardiomyocytes represents a potential new heart failure therapy. We hypothesized that inactivation of p63, a p53 gene family member, may help overcome human cell resistance to reprogramming. METHODS: p63 knockout ((−/−)) and knockdown murine embry...

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Detalhes bibliográficos
Publicado no:J Thorac Cardiovasc Surg
Main Authors: Patel, Vivekkumar, Singh, Vivek P., Pinnamaneni, Jaya Pratap, Sanagasetti, Deepthi, Olive, Jacqueline, Mathison, Megumi, Cooney, Austin, Flores, Elsa R., Crystal, Ronald G., Yang, Jianchang, Rosengart, Todd K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050095/
https://ncbi.nlm.nih.gov/pubmed/29716728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2018.03.162
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