Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming

Background The conversion of fibroblasts into induced cardiomyocytes may regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. The efficiency transdifferentiation is low, especially for human cells. We explored the leveraging of Hippo pathway intermediates to enha...

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Bibliografiska uppgifter
Huvudupphovsmän: Vivek P. Singh, Jaya P. Pinnamaneni, Aarthi Pugazenthi, Deepthi Sanagasetti, Megumi Mathison, James F. Martin, Jianchang Yang, Todd K. Rosengart
Materialtyp: Artigo
Språk:Inglês
Publicerad: Wiley 2021-12-01
Serie:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Ämnen:
cardiomyocytes
direct reprogramming
regeneration
Länkar:https://www.ahajournals.org/doi/10.1161/JAHA.121.022659
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