Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

BACKGROUND: In spontaneously hypertensive rats (SHR) we observed profound myocardial metabolic changes during early hypertension before development of cardiac dysfunction and left ventricular hypertrophy. In this study, we evaluated whether metformin improved myocardial metabolic abnormalities and s...

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Detalles Bibliográficos
Publicado en:J Am Heart Assoc
Autores principales: Li, Jie, Minćzuk, Krzysztof, Massey, James C., Howell, Nancy L., Roy, R. Jack, Paul, Soumen, Patrie, James T., Kramer, Christopher M., Epstein, Frederick H., Carey, Robert M., Taegtmeyer, Heinrich, Keller, Susanna R., Kundu, Bijoy K.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Brief Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428616/
https://ncbi.nlm.nih.gov/pubmed/32248762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015154
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