Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

BACKGROUND: In spontaneously hypertensive rats (SHR) we observed profound myocardial metabolic changes during early hypertension before development of cardiac dysfunction and left ventricular hypertrophy. In this study, we evaluated whether metformin improved myocardial metabolic abnormalities and s...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Li, Jie, Minćzuk, Krzysztof, Massey, James C., Howell, Nancy L., Roy, R. Jack, Paul, Soumen, Patrie, James T., Kramer, Christopher M., Epstein, Frederick H., Carey, Robert M., Taegtmeyer, Heinrich, Keller, Susanna R., Kundu, Bijoy K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428616/
https://ncbi.nlm.nih.gov/pubmed/32248762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015154
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