Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

The Scar/WAVE complex is the principal catalyst of pseudopod and lamellipod formation. Here we show that Scar/WAVE’s proline-rich domain is polyphosphorylated after the complex is activated. Blocking Scar/WAVE activation stops phosphorylation in both Dictyostelium and mammalian cells, implying that...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS Biol
Main Authors: Singh, Shashi Prakash, Thomason, Peter A., Lilla, Sergio, Schaks, Matthias, Tang, Qing, Goode, Bruce L., Machesky, Laura M., Rottner, Klemens, Insall, Robert H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425996/
https://ncbi.nlm.nih.gov/pubmed/32745097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000774
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker