Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

The Scar/WAVE complex is the principal catalyst of pseudopod and lamellipod formation. Here we show that Scar/WAVE’s proline-rich domain is polyphosphorylated after the complex is activated. Blocking Scar/WAVE activation stops phosphorylation in both Dictyostelium and mammalian cells, implying that...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Singh, Shashi Prakash, Thomason, Peter A., Lilla, Sergio, Schaks, Matthias, Tang, Qing, Goode, Bruce L., Machesky, Laura M., Rottner, Klemens, Insall, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425996/
https://ncbi.nlm.nih.gov/pubmed/32745097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000774
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