Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4(+) T cells post peptide loading

Smallpox and monkeypox pose severe threats to human health. Other orthopoxviruses are comparably virulent in their natural hosts, including ectromelia, the cause of mousepox. Disease severity is linked to an array of immunomodulatory proteins including the B22 family, which has homologs in all patho...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Forsyth, Katherine S., Roy, Nathan H., Peauroi, Elise, DeHaven, Brian C., Wold, Erik D., Hersperger, Adam R., Burkhardt, Janis K., Eisenlohr, Laurence C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425992/
https://ncbi.nlm.nih.gov/pubmed/32745153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008685
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