Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4(+) T cells post peptide loading

Smallpox and monkeypox pose severe threats to human health. Other orthopoxviruses are comparably virulent in their natural hosts, including ectromelia, the cause of mousepox. Disease severity is linked to an array of immunomodulatory proteins including the B22 family, which has homologs in all patho...

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Publicat a:PLoS Pathog
Autors principals: Forsyth, Katherine S., Roy, Nathan H., Peauroi, Elise, DeHaven, Brian C., Wold, Erik D., Hersperger, Adam R., Burkhardt, Janis K., Eisenlohr, Laurence C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425992/
https://ncbi.nlm.nih.gov/pubmed/32745153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008685
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