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Polypeptides derived from α-Synuclein binding partners to prevent α-Synuclein fibrils interaction with and take-up by cells

α-Synuclein (αSyn) fibrils spread from one neuronal cell to another. This prion-like phenomenon is believed to contribute to the progression of the pathology in Parkinson’s disease and other synucleinopathies. The binding of αSyn fibrils originating from affected cells to the plasma membrane of naïv...

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Veröffentlicht in:PLoS One
Hauptverfasser: Monsellier, Elodie, Bendifallah, Maya, Redeker, Virginie, Melki, Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425896/
https://ncbi.nlm.nih.gov/pubmed/32790707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0237328
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