The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

The intrinsically disordered protein α-synuclein (aSN) is, in its fibrillated state, the main component of Lewy bodies—hallmarks of Parkinson’s disease. Additional Lewy body components include glycosaminoglycans, including heparan sulfate proteoglycans. In humans, heparan sulfate has, in an age-depe...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Skaanning, Line K., Santoro, Angelo, Skamris, Thomas, Martinsen, Jacob Hertz, D’Ursi, Anna Maria, Bucciarelli, Saskia, Vestergaard, Bente, Bugge, Katrine, Langkilde, Annette Eva, Kragelund, Birthe B.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464290/
https://ncbi.nlm.nih.gov/pubmed/32824376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10081192
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