The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

The intrinsically disordered protein α-synuclein (aSN) is, in its fibrillated state, the main component of Lewy bodies—hallmarks of Parkinson’s disease. Additional Lewy body components include glycosaminoglycans, including heparan sulfate proteoglycans. In humans, heparan sulfate has, in an age-depe...

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Dades bibliogràfiques
Publicat a:Biomolecules
Autors principals: Skaanning, Line K., Santoro, Angelo, Skamris, Thomas, Martinsen, Jacob Hertz, D’Ursi, Anna Maria, Bucciarelli, Saskia, Vestergaard, Bente, Bugge, Katrine, Langkilde, Annette Eva, Kragelund, Birthe B.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464290/
https://ncbi.nlm.nih.gov/pubmed/32824376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10081192
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