Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth

Aggregation of proteins into amyloid deposits is the hallmark of several neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. The suggestion that intermediate oligomeric species may be cytotoxic has led to intensified investigations of pre-fibrillar oligomers, which are complicate...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nors Perdersen, Martin, Foderà, Vito, Horvath, Istvan, van Maarschalkerweerd, Andreas, Nørgaard Toft, Katrine, Weise, Christoph, Almqvist, Fredrik, Wolf-Watz, Magnus, Wittung-Stafshede, Pernilla, Vestergaard, Bente
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603703/
https://ncbi.nlm.nih.gov/pubmed/26020724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10422
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