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Differential effects of Cu(2+) and Fe(3+) ions on in vitro amyloid formation of biologically-relevant α-synuclein variants
Alterations in metal ion homeostasis appear coupled to neurodegenerative disorders but mechanisms are unknown. Amyloid formation of the protein α-synuclein in brain cells is a hallmark of Parkinson’s disease. α-Synuclein can bind several metal ions in vitro and such interactions may affect the assem...
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| Published in: | Biometals |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer Netherlands
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7295844/ https://ncbi.nlm.nih.gov/pubmed/32170541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-020-00234-4 |
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