Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation

[Image: see text] Small organic molecules that inhibit functional bacterial amyloid fibers, curli, are promising new antibiotics. Here we investigated the mechanism by which the ring-fused 2-pyridone FN075 inhibits fibrillation of the curli protein CsgA. Using a variety of biophysical techniques, we...

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Bibliografiska uppgifter
Huvudupphovsmän: Horvath, Istvan, Weise, Christoph F., Andersson, Emma K., Chorell, Erik, Sellstedt, Magnus, Bengtsson, Christoffer, Olofsson, Anders, Hultgren, Scott J., Chapman, Matthew, Wolf-Watz, Magnus, Almqvist, Fredrik, Wittung-Stafshede, Pernilla
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2012
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290101/
https://ncbi.nlm.nih.gov/pubmed/22260746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja209829m
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