Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth

Aggregation of proteins into amyloid deposits is the hallmark of several neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. The suggestion that intermediate oligomeric species may be cytotoxic has led to intensified investigations of pre-fibrillar oligomers, which are complicate...

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Vydáno v:Sci Rep
Hlavní autoři: Nors Perdersen, Martin, Foderà, Vito, Horvath, Istvan, van Maarschalkerweerd, Andreas, Nørgaard Toft, Katrine, Weise, Christoph, Almqvist, Fredrik, Wolf-Watz, Magnus, Wittung-Stafshede, Pernilla, Vestergaard, Bente
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603703/
https://ncbi.nlm.nih.gov/pubmed/26020724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10422
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