Wildtype and A30P Mutant Alpha-Synuclein Form Different Fibril Structures

Parkinson’s Disease (PD) is a neurodegenerative movement disorder affecting millions of people worldwide. One of the key players in the development of the disease is the protein α-synuclein (aSN), which aggregates in the brain of PD patients. The aSN mutant A30P has been reported to cause early-onse...

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Bibliographische Detailangaben
Hauptverfasser: Nielsen, Søren Bang, Macchi, Francesca, Raccosta, Samuele, Langkilde, Annette Eva, Giehm, Lise, Kyrsting, Anders, Svane, Anna Sigrid Pii, Manno, Mauro, Christiansen, Gunna, Nielsen, Niels Christian, Oddershede, Lene, Vestergaard, Bente, Otzen, Daniel Erik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701545/
https://ncbi.nlm.nih.gov/pubmed/23861789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067713
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