Wildtype and A30P Mutant Alpha-Synuclein Form Different Fibril Structures

Parkinson’s Disease (PD) is a neurodegenerative movement disorder affecting millions of people worldwide. One of the key players in the development of the disease is the protein α-synuclein (aSN), which aggregates in the brain of PD patients. The aSN mutant A30P has been reported to cause early-onse...

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Main Authors: Nielsen, Søren Bang, Macchi, Francesca, Raccosta, Samuele, Langkilde, Annette Eva, Giehm, Lise, Kyrsting, Anders, Svane, Anna Sigrid Pii, Manno, Mauro, Christiansen, Gunna, Nielsen, Niels Christian, Oddershede, Lene, Vestergaard, Bente, Otzen, Daniel Erik
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701545/
https://ncbi.nlm.nih.gov/pubmed/23861789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067713
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