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The Influence of Vesicle Size and Composition on α-Synuclein Structure and Stability

Monomeric α-synuclein (αSN), which has no persistent structure in aqueous solution, is known to bind to anionic lipids with a resulting increase in α-helix structure. Here we show that at physiological pH and ionic strength, αSN incubated with different anionic lipid vesicles undergoes a marked incr...

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Autors principals: Kjaer, Lars, Giehm, Lise, Heimburg, Thomas, Otzen, Daniel
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711279/
https://ncbi.nlm.nih.gov/pubmed/19348768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.12.3940
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