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Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs
The aggregation of the protein α-synuclein (α-Syn) leads to different synucleinopathies. We recently showed that structurally distinct fibrillar α-Syn polymorphs trigger either Parkinson’s disease or multiple system atrophy hallmarks in vivo. Here, we establish a structural-molecular basis for these...
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| Publicado no: | Biophys J |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7091477/ https://ncbi.nlm.nih.gov/pubmed/32059758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.01.022 |
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