α-synuclein assemblies sequester neuronal α3-Na(+)/K(+)-ATPase and impair Na(+) gradient

Extracellular α-synuclein (α-syn) assemblies can be up-taken by neurons; however, their interaction with the plasma membrane and proteins has not been studied specifically. Here we demonstrate that α-syn assemblies form clusters within the plasma membrane of neurons. Using a proteomic-based approach...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Shrivastava, Amulya Nidhi, Redeker, Virginie, Fritz, Nicolas, Pieri, Laura, Almeida, Leandro G, Spolidoro, Maria, Liebmann, Thomas, Bousset, Luc, Renner, Marianne, Léna, Clément, Aperia, Anita, Melki, Ronald, Triller, Antoine
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601662/
https://ncbi.nlm.nih.gov/pubmed/26323479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591397
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