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Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation

The aggregation of polyglutamine (polyQ)-containing proteins is at the origin of nine neurodegenerative diseases. Molecular chaperones prevent the aggregation of polyQ-containing proteins. The exact mechanism by which they interact with polyQ-containing, aggregation-prone proteins and interfere with...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Monsellier, Elodie, Redeker, Virginie, Ruiz-Arlandis, Gemma, Bousset, Luc, Melki, Ronald
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317008/
https://ncbi.nlm.nih.gov/pubmed/25505179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.603332
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