Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease

Many aggregation-prone proteins linked to neurodegenerative disease are post-translationally modified during their biogenesis. In vivo pathogenesis studies have suggested that the presence of post-translational modifications can shift the aggregate assembly pathway and profoundly alter the disease p...

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Publicado no:Neurobiol Dis
Main Authors: Callender, Julia A., Sevillano, Alejandro M., Soldau, Katrin, Kurt, Timothy D., Schumann, Taylor, Pizzo, Donald P., Altmeppen, Hermann, Glatzel, Markus, Esko, Jeffrey D., Sigurdson, Christina J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425694/
https://ncbi.nlm.nih.gov/pubmed/32454127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104955
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